An estrogen receptor mutant exhibiting hormone-independent transactivation and enhanced affinity for the estrogen response element.
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چکیده
منابع مشابه
Mouse Estrogen Receptor b Forms Estrogen Response Element- Binding Heterodimers with Estrogen Receptor a
The recent discovery that an additional estrogen receptor subtype is present in various rat tissues has advanced our understanding of the mechanisms underlying estrogen signaling. Here we report on the cloning of the cDNA encoding the mouse homolog of estrogen receptor-b (ERb) and the functional characterization of mouse ERb protein. ERb is shown to have overlapping DNA-binding specificity with...
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activity is also thought to be modulated by phosphorylation and dephosphorylation on multiple serine and tyrosine residues through more or less defined signaling pathways (5, 6). It is well accepted that the presence of ER identifies those breast cancer patients with a lower risk of disease recurrence and better survival, who may also have a better response to endocrine interven tions (7). The ...
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The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the steroid/nuclear receptor superfamily. Two genes encode mammalian ER: ERalpha and ERbeta. ER binds to specific DNA sequences called estrogen response elements (EREs) with high affinity and transactivates gene expression in response to estradiol (E(2)). The purpose of this review is to summarize how natural ...
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Thyroid hormones (T) and estrogens (E) are nuclear receptor ligands with at least two molecular mechanisms of action: (i) relatively slow genomic effects, such as the regulation of transcription by cognate T receptors (TR) and E receptors (ER); and (ii) relatively rapid nongenomic effects, such as kinase activation and calcium release initiated at the membrane by putative membrane receptors. Ge...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)49453-2